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Biochem Biophys Res Commun. 2003 Oct 24;310(3):677-80.

Endothelial nitric oxide synthase: a determinant of TNFalpha production by human monocytes/macrophages.

Author information

1
Pharmazentrum frankfurt, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany. H.Muehl@em.uni-frankfurt.de

Abstract

Until recently endothelial nitric oxide synthase (eNOS) has been associated exclusively with physiological functions, particularly in the cardiovascular system. However, increasing evidence has been accumulated that supports the concept for a role of eNOS in pathophysiology. In particular, detection of eNOS protein and activity in human monocytes/macrophages suggest an immunomodulatory role of this enzyme. Here, we review data that promote the hypothesis that by enhancing TNFalpha production, eNOS activity should be regarded as a novel pro-inflammatory parameter in human monocytes/macrophages.

PMID:
14550254
DOI:
10.1016/j.bbrc.2003.09.039
[Indexed for MEDLINE]

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