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Nucleic Acids Res. 1992 Nov 11;20(21):5677-86.

Differentially regulated malate synthase genes participate in carbon and nitrogen metabolism of S. cerevisiae.

Author information

1
Institut fuer Allgemeine Biochemie der Universitaet, Wien, Austria.

Abstract

We have isolated a second gene (MLS1), which in addition to DAL7, encodes malate synthase from S. cerevisiae. Expression of the two genes is specific for their physiological roles in carbon and nitrogen metabolism. Expression of MLS1, which participates in the utilization of non-fermentable carbon sources, is sensitive to carbon catabolite repression, but nearly insensitive to nitrogen catabolite repression. DAL7, which participates in catabolism of the nitrogenous compound allantoin, is insensitive to carbon catabolite repression, but highly sensitive to nitrogen catabolite repression. Results obtained with null mutations in these genes suggest that S. cerevisiae contains at least one and perhaps two additional malate synthase genes.

PMID:
1454530
PMCID:
PMC334402
DOI:
10.1093/nar/20.21.5677
[Indexed for MEDLINE]
Free PMC Article

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