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Biotechnol Adv. 2000 Nov 1;18(7):581-99.

Integrated processing of biotechnology products.

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  • 1Institute for Technical Chemistry, University of Hannover, Callinstrasse 3, D-30167 Hanover, Germany.


Integrated bioprocessing in which a potentially inhibitory product is continuously removed from the fermentation broth as it is produced, has important advantages in improving yield and conversion relative to conventional processes. This review discusses integrated processing for ethanol, butanol, organic acids, antibiotics, and other products. A variety of recovery operations can be used to isolate the product, as discussed. Use of some of the available options is compared.

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