Send to

Choose Destination
Mol Imaging Biol. 2002 May;4(3):238-44.

Optimizing imaging time for improved performance in oncology PET studies.

Author information

Biomedical Imaging Center, Department of Radiology, The University of Tennessee Medical Center at Knoxville, Knoxville, TN, USA.



The potential for improving the diagnostic performance of static positron imaging tomography (PET) by judiciously choosing optimum post-injection imaging times is investigated.


Dynamic and whole-body scan data, from 2-deoxy-2-[18F]fluoro-D-glucose (FDG) oncological studies, are analyzed for changing standardized uptake value (SUV) behavior with increasing post-injection times at either single- or multiple-bed positions. Model-based interpretations address d(SUV)/dt, shown to correlate with SUV, and the contrast ratio for a tumor and its surroundings. A method for correcting measurements to a standardized time is given.


Both data and model-based equations suggest that starting data acquisition later than the average 55 +/- 15 (SD) minutes post-injection reported in the FDG literature can improve contrast ratios. Considerations for choosing an optimum time from a clinical standpoint are listed.


It is concluded that the appropriate time for each particular protocol can be found with the aid of the information presented here. True optimization, however, remains a complex issue.


LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Loading ...
Support Center