Format

Send to

Choose Destination
Dev Cell. 2003 Oct;5(4):611-20.

The claudin-like megatrachea is essential in septate junctions for the epithelial barrier function in Drosophila.

Author information

1
Abteilung Molekulare Entwicklungsbiologie, Max-Planck-Institut für Biophysikalische Chemie, Am Fassberg, 37077 Göttingen, Germany.

Abstract

Vertebrate claudin proteins are integral components of tight junctions, which function as paracellular diffusion barriers in epithelia. We identified Megatrachea (Mega), a Drosophila transmembrane protein homologous to claudins, and show that it acts in septate junctions, the corresponding structure of invertebrates. Our analysis revealed that Mega has transepithelial barrier function similar to the claudins. Also, Mega is necessary for normal tracheal cell morphogenesis but not for apicobasal polarity or epithelial integrity. In addition, we present evidence that Mega is essential for localization of the septate junction protein complex Coracle/Neurexin. The results indicate that claudin-like proteins are functionally conserved between vertebrates and Drosophila.

PMID:
14536062
DOI:
10.1016/s1534-5807(03)00275-2
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center