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Dev Cell. 2003 Oct;5(4):530-2.

AP-2 makes room for rivals.

Author information

1
Department of Medicine, Harvard Medical School and Program in Membrane Biology, Renal Unit, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.

Abstract

Clathrin and the adaptor protein complex (AP-2) constitute the major coat components of clathrin-coated vesicles. In the September issues of the Journal of Cell Biology and the Journal of Biological Chemistry, three reports reveal that AP-2, while essential for internalization of transferrin, is not essential for internalization of EGF. These novel data suggest the intriguing possibility that the major role of AP-2 is in cargo recruitment, and not in assembly of functionally active clathrin-coated pits.

PMID:
14536052
[Indexed for MEDLINE]
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