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Dev Cell. 2003 Oct;5(4):530-2.

AP-2 makes room for rivals.

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Department of Medicine, Harvard Medical School and Program in Membrane Biology, Renal Unit, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.


Clathrin and the adaptor protein complex (AP-2) constitute the major coat components of clathrin-coated vesicles. In the September issues of the Journal of Cell Biology and the Journal of Biological Chemistry, three reports reveal that AP-2, while essential for internalization of transferrin, is not essential for internalization of EGF. These novel data suggest the intriguing possibility that the major role of AP-2 is in cargo recruitment, and not in assembly of functionally active clathrin-coated pits.

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