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Crit Rev Oral Biol Med. 2003;14(5):331-44.

Molecular genetic analysis of the virulence of oral bacterial pathogens: an historical perspective.

Author information

1
Department of Oral Biology, State University of New York, Buffalo, NY 14214, USA. kuramits@buffalo.edu

Abstract

This review will focus on the impact of molecular genetic approaches on elucidating the bacterial etiology of oral diseases from an historical perspective. Relevant results from the pre- and post-recombinant DNA periods will be highlighted, including the roles of gene cloning, mutagenesis, and nucleotide sequencing in this area of research. Finally, the impact of whole-genome sequencing on deciphering the virulence mechanisms of oral pathogens, along with new approaches to control these organisms, will be discussed.

PMID:
14530302
DOI:
10.1177/154411130301400504
[Indexed for MEDLINE]

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