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Mini Rev Med Chem. 2003 Nov;3(7):669-78.

Back to (non)-basics: recent developments in neutral and charge-balanced glycosidase inhibitors.

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  • 1School of Science, Griffith University, Nathan, QLD 4111, Australia.


Certain glycosidase inhibitors possess potent antiviral, antitumour and antidiabetic properties. Glyconic acid lactones, the earliest glycosidase inhibitors identified, have planar anomeric carbons that mimic the transition state of glycoside hydrolysis. Other classes include lactams, glycals, epoxides, halides and sulfonium ions, the latter based on the natural product salacinol from an antidiabetic herb.

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