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Nat Genet. 2003 Nov;35(3):217-8. Epub 2003 Oct 5.

The microRNA-producing enzyme Dicer1 is essential for zebrafish development.

Author information

1
Department of Functional Genomics, Hubrecht Laboratory, 3584 CT Utrecht, The Netherlands.

Abstract

MicroRNAs (miRNAs) are produced by the Dicer1 enzyme; the role of Dicer1 in vertebrate development is unknown. Here we report target-selected inactivation of the dicer1 gene in zebrafish. We observed an initial build-up of miRNA levels, produced by maternal Dicer1, in homozygous dicer1 mutants, but miRNA accumulation stopped after a few days. This resulted in developmental arrest around day 10. These results indicate that miRNA-producing Dicer1 is essential for vertebrate development.

PMID:
14528306
DOI:
10.1038/ng1251
[Indexed for MEDLINE]
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