Format

Send to

Choose Destination
EMBO Rep. 2003 Oct;4(10):939-43.

The ribosome and YidC. New insights into the biogenesis of Escherichia coli inner membrane proteins.

Author information

1
Department of Biochemistry and Biophysics, Arrhenius Laboratories, Stockholm University, SE-106 91 Stockholm, Sweden. degier@dbb.su.se

Abstract

In the bacterium Escherichia coli, inner membrane proteins (IMPs) are generally targeted through the signal recognition particle pathway to the Sec translocon, which is capable of both linear transport into the periplasm and lateral transport into the lipid bilayer. Lateral transport seems to be assisted by the IMP YidC. In this article, we discuss recent observations that point to a key role for the ribosome in IMP targeting and to the diverse roles of YidC in IMP assembly.

PMID:
14528263
PMCID:
PMC1326391
DOI:
10.1038/sj.embor.embor921
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center