The approaches to treatment of Langerhans' cell histiocytosis (LCH) have been as varied as the clinical presentation of the disease. The clinical course of localized LCH of bone is generally benign, and it tends to heal spontaneously in a period of months to years. If treatment is required, the disease can be controlled by local measures such as surgical curettement, low-dose irradiation, or intralesional infiltration with corticosteroids. We reviewed 15 children treated with intralesional infiltration of corticosteroids, either primarily for disease of bone (8 patients) or as adjunctive therapy for disseminated LCH (7 patients). Two patients developed complications as a result of this treatment method.