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Nat Cell Biol. 2003 Oct;5(10):845-50.

Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation.

Author information

  • 1Division of Biology, California Institute of Biology, 1200 East California Boulevard, Pasadena, CA 91125, USA. rlipford@caltech.edu

Abstract

A growing literature points to a fundamental role for the ubiquitin-proteasome degradation system (UPS) in transcription. Four recent publications add significant insight to our understanding of the connections between these processes. Each provides evidence that some aspect of the UPS can stimulate the activity of transcriptional activators. UPS might promote transcription by several mechanisms, and in some cases, even the final step of the UPS - proteolysis - might enhance activator function.

PMID:
14523392
DOI:
10.1038/ncb1003-845
[PubMed - indexed for MEDLINE]
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