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Sci Aging Knowledge Environ. 2003 Oct 1;2003(39):PE27.

Ceramide, stress, and a "LAG" in aging.

Author information

1
Ralph H. Johnson Veterans Affairs Medical Center, Department of Veteran Affairs, Charleston, SC 29401, USA. obeidl@musc.edu

Abstract

Recent studies have implicated the longevity assurance gene LAG1 in ceramide synthesis. In light of a role for ceramide in yeast and mammalian stress responses and mammalian cellular senescence, important connections are emerging between ceramide and organismal aging. In this Perspective, we examine the evidence for these connections in yeast, Drosophila, and mammals, and speculate on their implications.

PMID:
14523222
DOI:
10.1126/sageke.2003.39.pe27
[Indexed for MEDLINE]
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