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J Clin Invest. 2003 Oct;112(7):978-80.

Hepatoprotection via the IL-6/Stat3 pathway.

Author information

1
Bristol-Myers Squibb Co., PO Box 5100, 5 Research Parkway, Wallingford, Connecticut 06492, USA. rebecca.taub@bms.com

Abstract

Stat3 is a vital transcription factor that is activated downstream of the gp130 receptor, primarily via IL-6 signaling in adult liver. A new study demonstrates that Stat3 provides hepatoprotection against Fas-mediated apoptotic liver damage by two mechanisms: direct inactivation of caspases and reduction of reactive oxygen species.

PMID:
14523032
PMCID:
PMC198534
DOI:
10.1172/JCI19974
[Indexed for MEDLINE]
Free PMC Article

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