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Diagn Microbiol Infect Dis. 2003 Oct;47(2):415-9.

Sequential exposure of Aspergillus fumigatus to itraconazole and caspofungin: evidence of enhanced in vitro activity.

Author information

1
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA. dkontoyi@mdanderson.org

Abstract

We investigated the in vitro activity of sequential itraconazole and caspofungin against 10 isolates of Aspergillus fumigatus. Previous exposure of A. fumigatus to itraconazole resulted in dose-dependent enhanced effects of caspofungin and vice versa. Our finding suggests a preferential role for azole-caspofungin sequential combinations and merits further in vivo investigation.

PMID:
14522515
DOI:
10.1016/s0732-8893(03)00136-6
[Indexed for MEDLINE]

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