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J Am Coll Cardiol. 2003 Oct 1;42(7):1262-8.

Competing autonomic mechanisms precede the onset of postoperative atrial fibrillation.

Author information

1
Department of Anesthesiology and Critical Care Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. amard@mskcc.org

Abstract

OBJECTIVES:

This study was designed to evaluate autonomic changes preceding atrial fibrillation/flutter (AF) after thoracotomy.

BACKGROUND:

Autonomic fluctuations before the onset of postoperative AF have been reported but with conflicting results.

METHODS:

In 48 patients with postoperative AF, 2-h Holter recordings before the onset of AF were compared with corresponding data from 48 age- and gender-matched surgical controls without AF. Five-minute segments of heart rate variability (HRV) were studied using linear regression methods.

RESULTS:

There was a near-significant trend for the RR interval among patients with AF to be lower than controls (p = 0.06), whereas the standard deviation of RRs (p < 0.0001), root mean square of successive RR differences (p < 0.0001), proportion of RRs >50 ms different (p < 0.0001), low-frequency power (p = 0.0003) and its log (p < 0.0001), and high-frequency-power (p < 0.0001) and its log (p < 0.0001) were all significantly greater in patients with AF, respectively. In comparison to controls, AF patients had a significant decrease in RR interval (p = 0.02) and significant increments in all time- and frequency-domain analyses studied.

CONCLUSIONS:

In the period before the onset of postoperative AF, there are significant increases in HRV during a time when heart rate also increases. These novel findings are consistent with parasympathetic resurgence competing with increasing sympathetic activity as the triggering mechanism for postoperative AF.

PMID:
14522493
DOI:
10.1016/s0735-1097(03)00955-0
[Indexed for MEDLINE]
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