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Brain Res. 2003 Oct 31;989(1):122-7.

Glycine mediated alterations in intracellular pH.

Author information

1
Center for Neural Science, New York University, New York, NY 10003, USA.

Abstract

Glycinergic transmission shapes the coding properties of the lateral superior olivary nucleus (LSO). We investigated intracellular pH responses in the LSO to glycine using BCECF-AM in brain slices. With extracellular bicarbonate, glycine produced an alkalinization followed by an acidification while, in the nominal absence of bicarbonate, glycine produced acidifications. Separately, in whole-cell recordings from LSO neurons, glycine caused hyperpolarization followed by long-lasting depolarization. While the bicarbonate-dependent intracellular alkalinization could be related to chloride/bicarbonate exchange, bicarbonate-independent acidification may be triggered by depolarization.

PMID:
14519519
DOI:
10.1016/s0006-8993(03)03340-7
[Indexed for MEDLINE]

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