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Curr Opin Cell Biol. 2003 Oct;15(5):547-56.

Integrin avidity regulation: are changes in affinity and conformation underemphasized?

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Center for Blood Research, Harvard Medical School, Department of Pathology, 200 Longwood Avenue, Boston, MA 02115, USA.


Integrins play critical roles in development, wound healing, immunity and cancer. Central to their function is their unique ability to modulate dynamically their adhesiveness through both affinity- and valency-based mechanisms. Recent advances have shed light on the structural basis for affinity regulation and on the signaling mechanisms responsible for both affinity and valency modes of regulation.

[Indexed for MEDLINE]

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