Format

Send to

Choose Destination
Curr Opin Cell Biol. 2003 Oct;15(5):509-14.

Cadherin-mediated cellular signaling.

Author information

1
University of Nebraska Medical Center, 987696 Nebraska Medical Center, Omaha, NE 68198-7696, USA. mwheelock@unmc.edu

Abstract

Recent cadherin studies focusing on cellular signaling have shown that several pathways are activated by cadherin-mediated cell-cell contact. Cadherin-mediated contacts activate Rho family GTPases, regulate the availability of beta-catenin to participate in Wnt signaling, and function in receptor tyrosine kinase signaling. Although different classical cadherins bind to the same cytosolic proteins via their cytoplasmic tails, one message that is clear from the recent literature is that downstream signals emanating from cadherin-mediated contacts are both cadherin-specific and cell-context-specific.

PMID:
14519384
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center