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Emerg Infect Dis. 2003 Sep;9(9):1159-62.

Fluoroquinolone and macrolide treatment failure in pneumococcal pneumonia and selection of multidrug-resistant isolates.

Author information

1
Servicio de Microbiología, Hospital Donostia, San Sebastián, Spain. mikrobiol@terra.es

Abstract

Streptococcus pneumoniae serotype 3, isolated from a penicillin-allergic patient and initially susceptible to fluoroquinolones, macrolides, lincosamides, quinupristin-dalfopristin, and telithromycin, became resistant to all these drugs during treatment. Mutations in the parC and gyrA and in the 23S rRNA and the ribosomal protein L22 genes were detected in the resistant isolates.

PMID:
14519256
PMCID:
PMC3016791
DOI:
10.3201/eid0909.020810
[Indexed for MEDLINE]
Free PMC Article

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