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BMC Struct Biol. 2003 Sep 30;3:7.

Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site.

Author information

1
Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, 9600 Gudelsky Drive, Rockville, MD 20850, USA. jane.ladner@nist.gov

Abstract

BACKGROUND:

The protein encoded by the gene ybgI was chosen as a target for a structural genomics project emphasizing the relation of protein structure to function.

RESULTS:

The structure of the ybgI protein is a toroid composed of six polypeptide chains forming a trimer of dimers. Each polypeptide chain binds two metal ions on the inside of the toroid.

CONCLUSION:

The toroidal structure is comparable to that of some proteins that are involved in DNA metabolism. The di-nuclear metal site could imply that the specific function of this protein is as a hydrolase-oxidase enzyme.

PMID:
14519207
PMCID:
PMC239858
DOI:
10.1186/1472-6807-3-7
[Indexed for MEDLINE]
Free PMC Article
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