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Mech Dev. 2002 Dec;119 Suppl 1:S87-90.

FET-1: a novel W-linked, female specific gene up-regulated in the embryonic chicken ovary.

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Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.


A differential expression screen for sex-determining genes in the embryonic chicken gonad revealed a novel gene called Female Expressed Transcript 1 (FET-1). Fluorescent in situ hybridization analysis mapped FET-1 to the female specific W chromosome. Whole mount in situ hybridization showed that FET-1 expression was restricted to females and up-regulated in the cortex of the left gonad during the sex-determining period. Female specific expression was also observed in the embryonic caudal somites, neural tube and waste collection ducts.

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