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Yao Xue Xue Bao. 2003 Jul;38(7):555-8.

[Microbial transformation of sinenxan A, a rich constituent in callus cultures of Taxus].

[Article in Chinese]

Author information

1
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.

Abstract

AIM:

To study the microbial transformation of sinenxan A.

METHODS:

Choose two strains of Fungi (Mucor spinosus AS 3.3450 and Cunninghamella echinulata AS 3.3400) and a strain of bacterium (Proteus vulgaris AS 1.1208) to transform the substrate.

RESULTS:

Three products were obtained and identified as 10-deacetylsinenxan A1, 6 alpha-hydroxy-10-deacetylsinenxan A2 and 9 alpha-hydroxy-10-deacetylsinenxan A3 respectively.

CONCLUSION:

Sinenxan A is facile to be transformed by microorganisms, the 10-acetyl group of which is an active group.

PMID:
14515806
[Indexed for MEDLINE]
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