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J Infect Dis. 2003 Oct 1;188(7):1049-53. Epub 2003 Sep 15.

Beta-hemolysin-independent induction of apoptosis of macrophages infected with serotype III group B streptococcus.

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Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.


Group B streptococcus (GBS) induces apoptosis in macrophages. Growth conditions minimizing beta-hemolysin expression, such as high glucose, reduce apoptosis. We constructed an isogenic mutant strain of GBS 874391 lacking the beta-hemolysin structural gene cylE and investigated the role that beta-hemolysin plays in apoptosis of J774 macrophages. Viability of macrophages infected with wild-type or cylE GBS was similar and significantly less than that of macrophages infected with GBS grown in high-glucose media. Thus, apoptosis in GBS-infected macrophages is dependent not on beta-hemolysin but on a factor coregulated with beta-hemolysin by glucose.

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