Format

Send to

Choose Destination
See comment in PubMed Commons below
Science. 2003 Sep 26;301(5641):1925-8.

Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells.

Author information

  • 1Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia.

Abstract

The classical paradigm for dendritic cell function derives from the study of Langerhans cells, which predominate within skin epidermis. After an encounter with foreign agents, Langerhans cells are thought to migrate to draining lymph nodes, where they initiate T cell priming. Contrary to this, we show here that infection of murine epidermis by herpes simplex virus did not result in the priming of virus-specific cytotoxic T lymphocytes by Langerhans cells. Rather, the priming response required a distinct CD8alpha+ dendritic cell subset. Thus, the traditional view of Langerhans cells in epidermal immunity needs to be revisited to accommodate a requirement for other dendritic cells in this response.

PMID:
14512632
DOI:
10.1126/science.1087576
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center