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Science. 2003 Sep 26;301(5641):1859-60.

Cell biology. An age of instability.

Author information

1
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA. david_sinclair@hms.harvard.edu

Abstract

It is well established that as we age our cancer risk increases dramatically. As Sinclair explains in his Perspective, the link between cancer and aging is now solidified by new work in budding yeast (McMurray and Gottschling). As yeast cells age there is a marked increase in their genetic instability (a hallmark of cancer), which is independent of the mechanism that determines their life-span.

PMID:
14512612
DOI:
10.1126/science.1090465
[Indexed for MEDLINE]

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