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Acta Physiol Scand. 2003 Oct;179(2):173-7.

Lack of efficacy of 'naked' small interfering RNA applied directly to rat brain.

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Center for Genomics and Bioinformatics, Karolinska Institutet, SE, Stockholm, Sweden.


The intrastriatal infusions of 'naked' small interfering RNA (siRNA) targeted to dopamine D1 receptors (1.0-10.0 nmol over 3 days) did not reduce dopamine D1 receptor messenger RNA levels or receptor protein, assessed by [125I] SCH 23982 binding in intact rats. This was in contrast to results in vitro where a 76% reduction in dopamine D1 receptor ligand binding could be observed.


The results suggest that synthetic siRNA, when applied directly to rat brain, is not capable of inducing RNA interference.

[Indexed for MEDLINE]

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