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Clin Liver Dis. 2003 Aug;7(3):631-50, vii.

Treatment strategies for hepatitis C: intervention prior to liver transplant, pre-emptively or after established disease.

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Hospital Universitario La FE, Servicio de GastroenterologĂ­a y HepatologĂ­a, Avda Campanar 21 Valencia 46009, Spain.


Cirrhosis secondary to chronic hepatitis C virus (HCV) infection accounts for most liver transplants performed in the United States and European transplant centers. Given the high prevalence of HCV infection in the general population, the lack of consistently effective antiviral therapy, and the eventual progression to cirrhosis of a subset of those infected, predictions for the future are that the number of patients in need of transplantation will increase in the coming decade. In addition, viral infection recurs nearly universally leading to the development of chronic HCV in most recipients and progression to cirrhosis after a median of 9 to 12 years in a significant proportion of these recipients.

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