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Am J Pathol. 2003 Oct;163(4):1215-26.

T-cell-mediated autoimmunity: novel techniques to characterize autoreactive T-cell receptors.

Author information

1
Max-Planck Institute of Neurobiology, Martinsried, Germany. dornmair@neuro.mpg.de

Abstract

Histological samples of autopsy or biopsy tissue provide the best available evidence that autoreactive T cells are involved in the immunopathogenesis of many autoimmune diseases. However, morphology alone does not provide information on the antigen-specific T-cell receptor (TCR) of these cells, let alone on their antigen specificity. In this review article we discuss a number of emerging possibilities for identifying TCR sequences directly from biopsy tissue. We also review the methods for expressing presumably autoreactive TCR molecules and speculate on how the expressed TCR might be used to identify target antigens. Such information should eventually provide new insights into disease pathogenesis which lead to better therapies.

PMID:
14507631
PMCID:
PMC1868314
DOI:
10.1016/S0002-9440(10)63481-5
[Indexed for MEDLINE]
Free PMC Article
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