Format

Send to

Choose Destination
Trends Cell Biol. 2003 Oct;13(10):503-6.

Melanosome biogenesis: shedding light on the origin of an obscure organelle.

Author information

1
Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Gonda Center 6357B, Los Angeles, CA 90095, USA. edellangelica@mednet.ucla.edu

Abstract

Melanosomes are specialized intracellular organelles in which melanin pigments are synthesized and stored. The ontogenesis of these morphologically unique organelles, as well as their relationship to "conventional" organelles of the secretory and endocytic pathways, has for decades been a matter of study - and controversy. Recent work by the groups of Michael Marks and Gra├ža Raposo has uncovered the molecular mechanism that results in the formation of the lumenal striations characteristic of melanosome precursor organelles.

PMID:
14507476
DOI:
10.1016/j.tcb.2003.08.001
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center