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Nat Rev Mol Cell Biol. 2003 Sep;4(9):738-43. doi: 10.1038/nrm1201.

Priming virulence factors for delivery into the host.

Author information

1
Laboratory of Structural Microbiology, The Rockefeller University, Box 52, 1230 York Avenue, New York, New York 10021, USA. stebbins@rockeffeler.edu

Abstract

Several medically important Gram-negative bacterial pathogens inject virulence factors into host cells through a type III secretion system and specialized bacterial chaperones are required for their effective delivery. Recent structural work shows that these chaperones maintain virulence factors in a partially non-globular conformation that is primed for unfolding and translocation through the 'injectisome'.

PMID:
14506477
DOI:
10.1038/nrm1201
[Indexed for MEDLINE]

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