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Antimicrob Agents Chemother. 2003 Oct;47(10):3343-4.

Liposomal amphotericin B, and not amphotericin B deoxycholate, improves survival of diabetic mice infected with Rhizopus oryzae.

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1
Harbor-UCLA Research and Education Institute, Torrance, California 90502. UCLA School of Medicine, Los Angeles, California 90024, USA. Ibrahim@HUMC.EDU

Abstract

The efficacies of liposomal amphotericin B (LAmB) and amphotericin B deoxycholate (AmB) were compared in a diabetic murine model of hematogenously disseminated Rhizopus oryzae infection. At 7.5 mg/kg of body weight twice a day (b.i.d.), LAmB significantly improved overall survival compared to the rates of survival in both untreated control mice (P = 0.001) and mice treated with 0.5 mg of AmB per kg b.i.d. (P = 0.047). These data indicate that high-dose LAmB is more effective than AmB in treating murine disseminated zygomycosis.

PMID:
14506054
PMCID:
PMC201164
[Indexed for MEDLINE]
Free PMC Article
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