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Fertil Steril. 2003 Sep;80 Suppl 2:691-7.

Fraction of the peripheral blood concentration of CD56+/CD16-/CD3- cells in total natural killer cells as an indication of fertility and infertility.

Author information

1
Genetics and Biotechnology Department, Faculty of Biology, University of Athens, Ilissia, Greece. vmichou@hotmail.com

Abstract

OBJECTIVE:

To determine whether the peripheral blood concentration of CD56(+)/CD16(-)/CD3(-) cells, the main natural killer (NK) subpopulation that colonizes the endometrium in the middle and late secretory phase, can be related to fertility or infertility status.

DESIGN:

A case control study.

SETTING:

Immunopathology department of an infertility laboratory.

PATIENTS:

A total 99 women were selected (group I: consecutive spontaneous aborters, n = 25; group II: sporadic spontaneous aborters, n = 30; group III: infertile, n = 33; group IV: controls, n = 11).

INTERVENTION:

Immunophenotyping of women grouped according to their fertility status.

MAIN OUTCOME MEASURES:

Peripheral blood lymphocytes were examined by two- and three-color flow cytometry.

RESULTS:

A statistically significant association between endometrial-type peripheral blood (PB) NK cell concentrations and fertility status (groups I and IV vs. groups II and III) was documented. The %(/TOTAL PB)(CD56+CD16-CD3-) NK cells was significantly higher [1] in fertile (groups I and IV) than in sporadic aborters/infertile (groups II and III) women, [2] in group I when compared with groups II and III, and [3] in group IV when compared with groups II and III.

CONCLUSIONS:

This study indicates that diminished numbers of the %(/TOTAL PB)(CD56+CD16-CD3-) NK cells are related to sporadic aborters and infertile women. Thus, the fraction could be used as an indicator of subsequent successful implantation and maintenance of gestation.

PMID:
14505740
[Indexed for MEDLINE]
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