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Bioorg Med Chem Lett. 2003 Oct 20;13(20):3487-90.

Synthesis and testing of novel phenyl substituted side-chain analogues of classical cannabinoids.

Author information

1
Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee-Memphis, Memphis, TN 38163, USA.

Abstract

A series of novel phenyl substituted side-chain analogues of classical cannabinoids were synthesized and their CB1 and CB2 binding affinities were evaluated relative to Delta(8)-THC and compound 2. CB1 and CB2 binding assays indicate that the dimethyl and ketone analogues (3) and (6) display selectivity for the CB2 receptor in comparison to delta(8)-THC and compound 2. This study provides newer insights into the geometrical and functional group requirements of the ligand binding pockets of the CB1 and the CB2 receptors.

PMID:
14505654
[Indexed for MEDLINE]

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