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J Hum Genet. 2003;48(10):514-9. Epub 2003 Sep 19.

Interaction effects between estrogen receptor alpha gene, vitamin D receptor gene, age, and sex on bone mineral density in Chinese.

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1
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, 410081 Changsha, Hunan, PR China.

Abstract

We evaluated the interaction effects between the estrogen receptor alpha gene (ER-alpha), vitamin D receptor gene (VDR), age and sex on bone mineral density (BMD) in a sample of 340 unrelated males and 297 unrelated females from 401 Chinese nuclear families. Polymorphisms of PvuII and XbaI in the ER-alpha gene and ApaI in the VDR gene were detected by RFLP, and ER-alpha genotype was defined by the haplotype reconstructed according to the two loci. In the females, significant ER-VDR gene interaction ( P<0.05) was found on the lumbar spine BMD. Such interaction might account for approximately 1.0% of the BMD variation. At the femoral neck and trochanter, significant ER-age interaction effects were observed, which might explain 0.3% BMD variation for both skeletal sites. In the males, significant VDR-age interaction was found on femoral neck BMD ( P<0.05), and it accounted for 0.6% BMD variation. These interaction effects were largely dependent on gender groups, suggesting there may exist ER-VDR-sex, ER-age-sex, and VDR-age-sex complex interactions in our Chinese sample.

PMID:
14505233
DOI:
10.1007/s10038-003-0068-5
[Indexed for MEDLINE]
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