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Nat Rev Mol Cell Biol. 2003 Oct;4(10):777-85.

Initiation of DNA replication: lessons from viral initiator proteins.

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Cold Spring Harbor Laboratory, P.O. Box 100, 1 Bungtown Rd, Cold Spring Harbor, New York 11724, USA.


Initiator proteins are key components of the DNA replication machinery that determine where initiation will occur. In the past few years, due to a greatly improved understanding of what viral initiators look like and how they function, we can now identify the basic tasks that are required of initiators, as well as begin to comprehend what activities are required to perform these tasks. The improved knowledge of the viral initiators also demonstrates an unexpected level of conservation between different viral initiators, which might extend also to their cellular counterparts.

[Indexed for MEDLINE]

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