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Neurology. 2003 Sep 23;61(6):823-5.

CSF hypocretin levels in Guillain-Barré syndrome and other inflammatory neuropathies.

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Stanford University Center for Narcolepsy, Palo Alto, CA 94304, USA.


CSF hypocretin-1 was measured in 28 Guillain-Barré syndrome (GBS), 12 Miller-Fisher syndrome, 12 chronic inflammatory demyelinating polyneuropathy (CIDP), and 48 control subjects. Seven GBS subjects had undetectably low hypocretin-1 levels (<100 pg/mL). Hypocretin-1 levels were moderately reduced in an additional 11 GBS, 5 Miller-Fisher syndrome, and 1 CIDP subject. Low levels in GBS occurred early in the disease and were associated with upper CNS level abnormalities.

[Indexed for MEDLINE]

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