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Breast Cancer Res Treat. 2003 Aug;80(3):363-7.

Oncogene HER-2 in canine mammary gland carcinomas: an immunohistochemical and chromogenic in situ hybridization study.

Author information

1
Department of Comparative Pathology, Veterinary School, University of Córdoba, Córdoba, Spain. an1magoj@uco.es

Abstract

Immunohistochemical (IHC) HER-2/neu protein overexpression was found in 17.6% of canine mammary gland carcinomas, a percentage similar to that observed in human breast carcinoma, but there was no gene amplification by chromogenic in situ hybridization (CISH). Canine mammary carcinoma would be a suitable natural model of that subset of human breast carcinomas with HER-2 protein overexpression without gene amplification.

PMID:
14503809
DOI:
10.1023/a:1024929730165
[Indexed for MEDLINE]

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