Send to

Choose Destination
See comment in PubMed Commons below
J Craniofac Surg. 2003 Sep;14(5):747-8.

Cleft palate and toe malformations in a child with fetal methotrexate exposure.

Author information

University of Miami, Jackson Memorial Hospital, Miami, FL 33136, USA.


Methotrexate, a commonly administered chemotherapeutic agent, is a well-known human teratogen. Exposure of a fetus between 6 and 8 weeks of gestation is postulated to cause birth defects. However, fetal exposure to this drug after this critical period is thought to have little to no effect on eventual fetal development and growth. The authors report a case of an infant whose mother was exposed to methotrexate during pregnancy. The infant was evaluated at their clinic for an incomplete cleft palate and associated asymmetric deformities of the toes on both feet.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Support Center