Format

Send to

Choose Destination
Anesth Analg. 2003 Oct;97(4):1108-16.

The role of N-methyl-D-aspartate (NMDA) receptors in pain: a review.

Author information

1
Department of Anesthesiology, Niigata University School of Medicine, Asahimachi 1-757, Niigata 951-8510, Japan. abpetr@med.niigata-u.ac.jp

Abstract

There is accumulating evidence to implicate the importance of N-methyl-D-aspartate (NMDA) receptors to the induction and maintenance of central sensitization during pain states. However, NMDA receptors may also mediate peripheral sensitization and visceral pain. NMDA receptors are composed of NR1, NR2 (A, B, C, and D), and NR3 (A and B) subunits, which determine the functional properties of native NMDA receptors. Among NMDA receptor subtypes, the NR2B subunit-containing receptors appear particularly important for nociception, thus leading to the possibility that NR2B-selective antagonists may be useful in the treatment of chronic pain.

PMID:
14500166
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center