Send to

Choose Destination
Cancer Genet Cytogenet. 2003 Oct 1;146(1):73-6.

X chromosome inactivation in cervical cancer patients.

Author information

Department of Medical Genetics, Rikshospitalet, Oslo, Norway.


Development of cervical carcinomas is strongly associated with presence of human papilloma virus (HPV). Recently we found that young patients with breast cancer had a higher frequency of skewed X inactivation in peripheral blood cells, indicating an effect of X-linked genes on breast cancer development. In this study, we investigated the frequency of skewed X-inactivation pattern in blood and tumor biopsies from patients with cervical cancer. No difference in the frequency of skewed X inactivation in blood was found between 142 patients and 437 age-matched controls. Elderly females have a higher frequency of skewed X inactivation in blood cells than younger females. An age effect was confirmed in this study for blood cells in both patients and controls. A tendency to an age effect was also found in the tumor biopsies. The correlation between X inactivation in blood and biopsies was 0.39 (P<0.001), showing that the X inactivation in biopsies to some degree reflects skewing in blood. Furthermore, of eight patients with a skewing of > or =75% in biopsies, seven patients had a skewing in the same direction in their blood cells (P=0.03). Our results indicate that if X-inactivation analysis is to be used in clonality studies of cervical cancers, it is essential to consider both the age and the X-inactivation pattern in blood cells.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science Icon for Norwegian BIBSYS system
Loading ...
Support Center