Glucose 1,6-bisphosphate and fructose 2,6-bisphosphate in muscle from healthy humans and chronic alcoholic patients

J A Cadefau; V Andrés; J Carreras; M Vernet; J M Grau; A Urbano-Márquez; R Cussó

Glucose 1,6-bisphosphate and fructose 2,6-bisphosphate in muscle from healthy humans and chronic alcoholic patients

Alcohol Alcohol. 1992 May;27(3):253-6.

Authors

J A Cadefau¹, V Andrés, J Carreras, M Vernet, J M Grau, A Urbano-Márquez, R Cussó

Affiliation

¹ Unidad de Bioquímica de la Facultad de Medicina, Universidad de Barcelona, Spain.

PMID: 1449560

Abstract

Chronic alcohol intake produces an increase in the concentration of glucose 1,6-bisphosphate and fructose 2,6-bisphosphate in human muscle before the first sign of myopathy appears. When myopathy was present both sugars decreased to the levels of healthy humans. These changes could contribute to the decline in skeletal muscle performance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Alcoholism / pathology*
Alcoholism / rehabilitation
Biopsy
Fructosediphosphates / metabolism*
Glucose-6-Phosphate* / analogs & derivatives*
Glucosephosphates / metabolism*
Glycolysis / drug effects
Glycolysis / physiology
Humans
Male
Middle Aged
Muscles / pathology*
Muscular Diseases / pathology

Substances

Fructosediphosphates
Glucosephosphates
Glucose-6-Phosphate
fructose 2,6-diphosphate
glucose-1,6-bisphosphate