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Am J Gastroenterol. 1992 Dec;87(12):1789-91.

Treatment of intractable hiccup with baclofen: results of a double-blind randomized, controlled, cross-over study.

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Department of Medicine, Baylor College of Medicine, Houston, Texas.


Four patients with intractable hiccup were treated in a double-blind, randomized, placebo, cross-over study with an analogue of gamma-aminobutyric acid, Baclofen. There was a consistent and statistically significant (p = 0.03) improvement in hiccup severity with Baclofen, both subjectively (p = 0.03) and by hiccup-free periods (p = 0.003). The actual frequency of hiccup was not significantly altered by the medication. We propose that the mechanical aspects of hiccup are reduced by Baclofen, leading to a perceptual blockage and a decrease in the reflex severity induced by the gamma-aminobutyric acid analogue. We conclude that this medication may be useful for the treatment of intractable hiccup.

[Indexed for MEDLINE]

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