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Nature. 1992 Nov 26;360(6402):313-9.

Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice.

Author information

1
Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030.

Abstract

The inhibins are alpha:beta heterodimeric growth factors that are members of the transforming growth factor-beta family. To understand the physiological roles of the inhibins in mammalian development and reproduction, a targeted deletion of the alpha-inhibin gene was generated by homologous recombination in mouse embryonic stem cells. Mice homozygous for the null allele (inhibin-deficient) initially develop normally but every mouse ultimately develops mixed or incompletely differentiated gonadal stromal tumours either unilaterally or bilaterally. Inhibin is thus a critical negative regulator of gonadal stromal cell proliferation and the first secreted protein identified to have tumour-suppressor activity.

PMID:
1448148
DOI:
10.1038/360313a0
[Indexed for MEDLINE]

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