Format

Send to

Choose Destination
Arthritis Rheum. 1992 Nov;35(11):1381-6.

Suppression of renal disease and arthritis, and prolongation of survival in MRL-lpr mice treated with an extract of Tripterygium wilfordii Hook f.

Author information

1
Department of Medicine, Montreal General Hospital Research Institute, Quebec, Canada.

Abstract

OBJECTIVE:

Treatment of MRL-lpr/lpr mice with Tripterygium wilfordii Hook f (TWHf) to evaluate its effects on mortality, renal disease, and arthritis.

METHODS:

Mice were fed water (group A, control), TWHf (group B), or first water and then TWHf (group C) from age 7 weeks until age 21 weeks.

RESULTS:

Arthritis and glomerulonephritis were decreased in groups B and C mice, and survival was increased in group B mice.

CONCLUSION:

TWHf decreases the mortality rate, and severity of glomerulonephritis and arthritis in MRL-lpr/lpr mice.

PMID:
1445458
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center