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Science. 1992 Nov 13;258(5085):1156-9.

B cells turn off virgin but not memory T cells.

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  • 1Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, MD 20892.

Abstract

There are three possible outcomes when a T cell recognizes a cell bearing a self or foreign antigen. (i) The T cell is not sufficiently signaled and is unaffected. (ii) The T cell is activated. (iii) The T cell is turned off. The differentiation state of the T cell is critical to the outcome. Although both virgin and memory T cells can be activated by antigens presented by "professional" antigen-presenting cells such as dendritic cells, they differ in their responses to B cells. Experienced T cells respond to antigen presented by B cells, whereas virgin T cells are rendered tolerant. These findings may relate to the phenomena of low- and high-zone tolerance, neonatal tolerance, and the beneficial effect of blood transfusions on allograft survival.

PMID:
1439825
[PubMed - indexed for MEDLINE]
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