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Science. 1992 Oct 30;258(5083):766-70.

What if Minkowski had been ageusic? An alternative angle on diabetes.

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1
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235.

Abstract

Despite decades of intensive investigation, the basic pathophysiological mechanisms responsible for the metabolic derangements associated with diabetes mellitus have remained elusive. Explored here is the possibility that traditional concepts in this area might have carried the wrong emphasis. It is suggested that the phenomena of insulin resistance and hyperglycemia might be more readily understood if viewed in the context of underlying abnormalities of lipid metabolism.

PMID:
1439783
[Indexed for MEDLINE]
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