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Nature. 1992 Oct 29;359(6398):801-6.

Crystal structure of staphylococcal enterotoxin B, a superantigen.

Author information

1
Biocrystallography Laboratory, VA Medical Center, Pittsburgh, Pennsylvania 15240.

Abstract

The three-dimensional structure of staphylococcal enterotoxin B, which is both a toxin and a super-antigen, has been determined to a resolution of 2.5 A. The unusual main-chain fold containing two domains may represent a general motif adopted by all staphylococcal enterotoxins. The T-cell receptor binding site encompasses a shallow cavity formed by both domains. The MHCII molecule binds to an adjacent site. Another cavity with possible biological activity was also identified.

PMID:
1436058
DOI:
10.1038/359801a0
[Indexed for MEDLINE]

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