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J Virol. 1992 Dec;66(12):7549-54.

Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5.

Author information

1
Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City 66103.

Abstract

Processing of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5 could be mediated by the catalytically active NS3 protease domain and NS2B in trans at the dibasic sites NS3-NS4A and NS4B-NS5. Subcellular localization of the unprocessed precursor NS3-NS4A-NS4B-NS5 showed that it was confined to a distinct subcellular organelle in the cytoplasm, which was distinct from the distribution of the mature NS5.

PMID:
1433530
PMCID:
PMC240467
[Indexed for MEDLINE]
Free PMC Article

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