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J Med Vet Mycol. 1992;30(4):275-80.

Determination of plasma (1-->3)-beta-D-glucan: a new diagnostic aid to deep mycosis.

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Department of Clinical Pathology, Jichi Medical School, Tochigi, Japan.


We present additional evidence that plasma from patients with deep-seated mycoses contains (1-->3)-beta-D-glucan. Digestion of such samples with endo-(1-->3)-beta-D-glucanase completely abolished the ability of the plasma to activate factor-G, a horseshoe crab coagulation enzyme that is extremely sensitive to this polysaccharide. Measurement of plasma (1-->3)-beta-D-glucan is a promising method for the diagnosis of deep-seated mycoses and for monitoring the response of these infections to antifungal therapy.

[Indexed for MEDLINE]

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